Part I Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease

Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease

Peter L. Collins, Rachel Fearns, and Barney S. Graham

Clinical and Epidemiologic Features of Respiratory Syncytial Virus
Caroline B. Hall, Eric A. F. Simőes, and Larry J. Anderson

Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity

José A. Melero and Martin L. Moore

Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins

Jason S. McLellan, William C. Ray and Mark E. Peeples

Respiratory Syncytial Virus and Reactive Airway Disease

Matthew T. Lotz, Martin L. Moore, and R. Stokes Peebles, Jr.

Part II Host Response to Infection and Genetics of Disease

Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches

Eun Hwa Choi, Hoan Jong Lee, and Stephen J. Chanock

Innate Immune Responses to Respiratory Syncytial Virus Infection

Sumanta Mukherjee and Nicholas W. Lukacs

The Adaptive Immune Response to Respiratory Syncytial Virus

Steven. M. Varga and Thomas J. Braciale

Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons

Sailen Barik

Host Gene Expression and Respiratory Syncytial Virus Infection

Ralph A. Tripp, Asuncion Mejias, and Octavio Ramilo

Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus

Allison M.W. Malloy, Ann R. Falsey, and Tracy J. Ruckwardt

Part III Vaccine Platforms and Treatment Options

Respiratory Syncytial Virus Disease: Prevention and Treatment

Helen Y. Chu and Janet A. Englund

Live-Attenuated Respiratory Syncytial Virus Vaccines

Ruth A. Karron, Ursula J. Buchholz, and Peter L. Collins

Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus

Trudy G. Morrison and Edward E. Walsh

Gene-Based Vaccine Approaches for Respiratory Syncytial Virus

Rebecca J. Loomis and Philip R. Johnson

Part IV Animal and Tissue Culture Models of Infection

Bovine Model of Respiratory Syncytial Virus Infection

Geraldine Taylor

The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection

Marina S. Boukhvalova and Jorge C.G. Blanco

The Mouse Model of Respiratory Syncytial Virus Disease

Peter J. Openshaw

Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection

Raymond J. Pickles

Part V Conclusions

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Barney S. Graham and Larry J. Anderson