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Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms

Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms

          
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About the Book

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.


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Product Details
  • ISBN-13: 9781461412212
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Depth: 19
  • Height: 262 mm
  • No of Pages: 184
  • Series Title: Advances in Experimental Medicine and Biology
  • Sub Title: Roles in Signaling and Disease Mechanisms
  • Weight: 568 gr
  • ISBN-10: 1461412218
  • Publisher Date: 30 Jan 2012
  • Binding: Hardback
  • Edition: 1
  • Language: English
  • Returnable: Y
  • Spine Width: 15 mm
  • Volume: 729
  • Width: 183 mm


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