Home > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Causes and Consequences of Cerebral Small Vessel Disease. the Run DMC Study: A Prospective Cohort Study. Study Rationale and Protocol: A Prospective Cohort Study. Study Rationale and Protocol
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Causes and Consequences of Cerebral Small Vessel Disease. the Run DMC Study: A Prospective Cohort Study. Study Rationale and Protocol: A Prospective Cohort Study. Study Rationale and Protocol

Causes and Consequences of Cerebral Small Vessel Disease. the Run DMC Study: A Prospective Cohort Study. Study Rationale and Protocol: A Prospective Cohort Study. Study Rationale and Protocol

          
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About the Book

Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD become demented or get parkinsonism. This might be explained by the diversity of underlying pathology of both white matter lesions (WML) and the normal appearing white matter (NAWM). Both cannot be properly appreciated with conventional MRI. Diffusion tensor imaging (DTI) provides alternative information on microstructural white matter integrity. The association between SVD, its microstructural integrity, and incident dementia and parkinsonism has never been investigated. The follow up of the RUN DMC study has the potential to further unravel the causes and possibly better predict the consequences of changes in white matter integrity in elderly with SVD by using relatively new imaging techniques. When proven, these changes might function as a surrogate endpoint for cognitive and motor function in future therapeutic trials. Our data could furthermore provide a better understanding of the pathophysiology of cognitive and motor disturbances in elderly with SVD. The execution and completion of the follow up of our study might ultimately unravel the role of SVD on the microstructural integrity of the white matter in the transition from "normal" aging to cognitive and motor decline and impairment and eventually to incident dementia and parkinsonism. Proceeds from the sale of this book go to the support of an elderly disabled person.


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Product Details
  • ISBN-13: 9781515250654
  • Publisher: Createspace Independent Publishing Platform
  • Publisher Imprint: Createspace Independent Publishing Platform
  • Height: 276 mm
  • No of Pages: 38
  • Series Title: English
  • Weight: 14528 gr
  • ISBN-10: 1515250652
  • Publisher Date: 29 Jul 2015
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 3 mm
  • Width: 213 mm


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Causes and Consequences of Cerebral Small Vessel Disease. the Run DMC Study: A Prospective Cohort Study. Study Rationale and Protocol: A Prospective Cohort Study. Study Rationale and Protocol
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