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Cardio Metabolic Risk Factors of Diabetic and Non Diabetic Mothers

Cardio Metabolic Risk Factors of Diabetic and Non Diabetic Mothers

          
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About the Book

Intrauterine exposure to hyperglycemia predisposes the offspring to increased risk of obesity,

glucose intolerance and cardiovascular (CV) risk. A longitudinal study in the Pima Indians

showed that offspring of diabetic mothers (ODM) have an increased risk of obesity, impaired

glucose tolerance (IGT) and type 2 diabetes (T2D) demonstrable as early as 5 years of age.

The SEARCH case-control study in the USA concluded that 47.2% of T2D in youth could be

attributed to intrauterine exposure to maternal diabetes and obesity. These studies support the

'fuel-mediated teratogenesis' concept of Pedersen and Frienkel which states that excess transplacental

transfer of glucose, lipids and amino acids in a diabetic pregnancy results in foetal

hyperglycaemia, hyperinsulinemia, and excess growth, resulting in an increased risk of obesity

and diabetes.

Most of the available literature is from the Western world where they have focused on

childhood, adolescence and in a few studies adulthood. The Mysore Parthenon birth cohort,

specifically set up to examine the long-term effects of GDM on the offspring, is the only study

from India. It showed higher occurrence of CV risk markers (adiposity, higher glucose and

insulin concentrations, insulin resistance and blood pressure) in ODM during childhood and

adolescence. However, they have followed only a limited number of ODM (n=45). There is a

need for larger studies in Indian population to explore the risk of hyperglycemia in offspring

of Gestational Diabetes Mellitus (GDM) women and studying its contribution to the escalating

epidemic of diabetes in the young would be of great interest.

With this in view, the current study was planned to investigate the prevalence of cardiometabolic

risk factors (adiposity/obesity, glucose intolerance, insulin resistance, β-cell

dysfunction, dyslipidemia, high blood pressure) in offspring of women with diabetic pregnancy

compared with offspring not exposed to in utero diabetes, we also investigated the effect of

offspring's lifestyle in the modification of cardio-metabolic risk. Our study will add to the

understanding of intergenerational programming of diabetes and cardio-metabolic risk in

children born in diabetic pregnancies in India, where role of maternal undernutrition is well

documented


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Product Details
  • ISBN-13: 9785470887146
  • Publisher: Independent Author
  • Publisher Imprint: Independent Author
  • Height: 229 mm
  • No of Pages: 188
  • Spine Width: 10 mm
  • Width: 152 mm
  • ISBN-10: 5470887146
  • Publisher Date: 28 Nov 2022
  • Binding: Paperback
  • Language: English
  • Returnable: Y
  • Weight: 258 gr


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