This book gives insight as to why many-including an unbroken line of some of the most credentialled and highly regarded scientists spanning this greater than 200 year debate-are not convinced there is benefit in vaccinating. It does so without raising the prospect of conspiracy amongst industry and/or government, instead focusing on situational-opacity in Big Data World and the lack of controlled experimental evidence. In light of the growing prospect of penalty-enforced mandatory vaccination, the author investigates precisely how we as a scientific culture have convinced ourselves that vaccination is beneficial.The most relied upon evidence in support of vaccination is analysed in this book. Controlled experiments and many other studies that have sought to prove its benefit are featured, with particular emphasis on those that are championed by the pro-vaccination lobby. Of course, the author gives due regard to celebrated examples of claimed triumph, e.g. polio and smallpox, and, without dabbling in conspiracy theories, analyses the official track record.The book peers into the phenomenon of 'disease genesis': what we as a scientific culture have come to understand of it, and how we have theorised about it. It includes a look at the various experiments we have conducted to formulate, and test, our hypotheses, and the relationship between the germ theory and the 'vaccines save lives' theory.How do we distinguish between that which does exist and that which might? How might we distinguish unseeable phenomena that we convince ourselves exist but, for all we know, might not? One way is to arrange circumstances such that the phenomena, if they exist, will emerge with a degree of clarity. This is a scientific approach. With the claimed life-saving effect of vaccination, what circumstances have we arranged, and what phenomena have been observed and measured? Throughout my thorough investigation, I have been unable to locate even one controlled experiment that has produced an observable lifesaving effect for vaccination. Indeed, I have been unable to locate robust evidence that it even lowers disease incidence.How, then, have we satisfied ourselves that such a lifesaving effect really does exist for vaccination? For one, we have discovered that by vaccinating we can sometimes alter the likelihood that a certain defined set of symptoms will occur for a period of time. Thus we conclude that it must prevent disease per se. We have also discovered that vaccines can make one less likely to test positive for the microbe targeted by the vaccine-making team. During these kinds of trials, where the recipients of the vaccine are found to be less likely to pass positive for the targeted microbe compared to saline-injected placebo recipients: as long as the overall disease incidence isn't significantly higher in the vaccinated group, the vaccine is considered successful in proving safety and efficacy, in trials ranging from 3 to 28 months.We are yet to record a series of properly controlled trials, in any species, measuring and reporting all disease incidence and mortality, and share the results. The closest we appear to have come to doing this is an example discussed in Chapter 2 'Demonstrating the Benefit'.