About the Book

Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately.

This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.

The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.

About the Author

Lewis Cantley, Harvard Medical School Tony Hunter, The Salk Institute Richard Sever, Cold Spring Harbor Laboratory Jeremy Thorner, University of California, Berkeley

Table of Contents:
Preface Foreword - Edmond Fischer SECTION I: GENERAL PRINCIPLES AND MECHANISMS 1 Signals and Receptors - Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind 2 Protein Regulation in Signal Transduction - Michael J. Lee and Michael B. Yaffe 3 Second Messengers - Alexandra C. Newton, Martin D. Bootman, and John D. Scott 4 Signaling Networks: Information Flow, Computation, and Decision Making - Evren U. Azeloglu and Ravi Iyengar SECTION II: SIGNALING PATHWAYS MAP Kinase Pathways - Deborah K. Morrison The PI3K-PKB/Akt Pathway - Brian A. Hemmings and David F. Restuccia mTOR Signaling - Mathieu Laplante and David M. Sabatini Calcium Signaling - Martin D. Bootman The Cyclic AMP Pathway - Paolo Sassone-Corsi Wnt Signaling - Roel Nusse Hedgehog Signaling - Philip W. Ingham Notch Signaling - Raphael Kopan Signaling by the TGFß Superfamily - Jeffrey L. Wrana The JAK/STAT Pathway - Douglas A. Harrison Toll-Like Receptor Signaling - Kian-Huat Lim and Louis M. Staudt Immunoreceptor Signaling - Lawrence E. Samelson Signaling by Nuclear Receptors - Richard Sever and Christopher K. Glass The Hippo Pathway - Kieran F. Harvey and Iswar K. Hariharan SECTION III: SIGNALING PROCESSES 5 Signaling Pathways that Control Cell Proliferation - Robert J. Duronio and Yue Xiong 6 Signaling Pathways that Regulate Cell Division - Nicholas Rhind and Paul Russell 7 Signaling in Control of Cell Growth and Metabolism - Patrick S. Ward and Craig B. Thompson 8 Signaling Networks that Regulate Cell Migration - Peter Devreotes and Alan Rick Horwitz 9 Signaling Pathways in Cell Polarity - Luke Martin McCaffrey and Ian G. Macara 10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning - Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo 11 Signaling by Sensory Receptors - David Julius and Jeremy Nathans 12 Synaptic Signaling in Learning and Memory - Mary B. Kennedy 13 Signaling in Muscle Contraction - Ivana Y. Kuo and Barbara E. Ehrlich 14 Organismal Carbohydrate and Lipid Homeostasis - D. Grahame Hardie 15 Signaling in Innate Immunity and Inflammation - Kim Newton and Vishva M. Dixit 16 Signaling in Lymphocyte Activation - Doreen Cantrell 17 Vertebrate Reproduction - Sally Kornbluth and Rafael Fissore 18 Cell Signaling and Stress Responses - Gökhan S. Hotamisligil and Roger J. Davis 19 Cell Death Signaling - Douglas R. Green and Fabien Llambi 20 Subversion of Cell Signaling by Pathogens - Neal M. Alto and Kim Orth 21 Signal Transduction in Cancer - Richard Sever and Joan S. Brugge 22 Outlook - Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever Index