Sir Leicester Dedlock and his wife Honoria live on his estate at Chesney Wold. Unknown to Sir Leicester, before she married, Lady Dedlock had a lover, Captain Hawdon, and had a daughter by him. Lady Dedlock believes her daughter is dead.
The daughter, Esther, is in fact alive and being raised by Miss Barbary, Lady Dedlock's sister. Esther does not know Miss Barbary is her aunt. After Miss Barbary dies, John Jarndyce becomes Esther's guardian and assigns the Chancery lawyer "Conversation" Kenge to take charge of her future. After attending school for six years, Esther moves in with him at Bleak House.
Jarndyce simultaneously assumes custody of two other wards, Richard Carstone and Ada Clare (who are both his and one another's distant cousins). They are beneficiaries in one of the wills at issue in Jarndyce and Jarndyce; their guardian is a beneficiary under another will, and the two wills conflict. Richard and Ada soon fall in love, but though Mr Jarndyce does not oppose the match, he stipulates that Richard must first choose a profession. Richard first tries a career in medicine, and Esther meets Allan Woodcourt, a physician, at the house of Richard's tutor. When Richard mentions the prospect of gaining from the resolution of Jarndyce and Jarndyce, John Jarndyce beseeches him never to put faith in what he calls "the family curse".
Meanwhile, Lady Dedlock is also a beneficiary under one of the wills. Early in the book, while listening to the reading of an affidavit by the family solicitor, Mr Tulkinghorn, she recognises the handwriting on the copy. The sight affects her so much she almost faints, which Tulkinghorn notices and investigates. He traces the copyist, a pauper known only as "Nemo", in London. Nemo has recently died, and the only person to identify him is a street-sweeper, a poor homeless boy named Jo, who lives in a particularly grim and poverty-stricken part of the city known as Tom-All-Alone's ("Nemo" is Latin for "nobody").
On Christmas Eve, around 1812, Pip, an orphan who is about seven years old, encounters an escaped convict in the village churchyard, while visiting the graves of his parents and siblings. Pip now lives with his abusive elder sister and her kind husband Joe Gargery, a blacksmith. The convict scares Pip into stealing food and a file. Early on Christmas morning Pip returns with the file, a pie and brandy. During Christmas Dinner that evening, at the moment Pip's theft is about to be discovered, soldiers arrive and ask Joe to repair some shackles. Joe and Pip accompany them as they recapture the convict who is fighting with another escaped convict. The first convict confesses to stealing food from the smithy.
A year or two later, Miss Havisham, a wealthy spinster who still wears her old wedding dress and lives as a recluse in the dilapidated Satis House, asks Mr Pumblechook, a relation of the Gargery's, to find a boy to visit her. Pip visits Miss Havisham and falls in love with her adopted daughter Estella. Estella remains aloof and hostile to Pip, which Miss Havisham encourages. Pip visits Miss Havisham regularly, until he is old enough to learn a trade.
Joe accompanies Pip for the last visit, when she gives the money for Pip to be bound as apprentice blacksmith. Joe's surly assistant, Dolge Orlick, is envious of Pip and dislikes Mrs Joe. When Pip and Joe are away from the house, Mrs Joe is brutally attacked, leaving her unable to speak or do her work. Orlick is suspected of the attack. Mrs Joe becomes kind-hearted after the attack. Pip's former schoolmate Biddy joins the household to help with her care.