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Biomateriales, factores de crecimiento y células para regeneración de cartílago

Biomateriales, factores de crecimiento y células para regeneración de cartílago

          
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About the Book

Tesis Doctoral / Disertación del año 2017 en eltema Farmacología, Nota: Sobresaliente "cum laude", Universidad de La Laguna Teneriffa (Facultad de Ciencias de la Salud. Sección de Farmacia.), Idioma: Español, Resumen: El cartílago articular constituye una variedad de tejido conjuntivo que recubre los extremos de las articulaciones sinoviales proveyendo una superficie de baja fricción y distribuyendo la carga al hueso subcondral subyacente. El cartílago se caracteriza por su baja densidad celular y por la ausencia de vascularización e invervación, lo que hace muy difícil su autoreparación tras una lesión. El escaso éxito de los tratamientos convencionales aplicados hasta el momento, ha potenciado en los últimos años el desarrollo de la ingeniería de tejidos para la reparación de lesiones del cartílago. En este trabajo, se elaboran y ensayan dos sistemas biocompatibles, evaluando su capacidad condrogénica en la reparación de un defecto osteocondral crítico en fémur de conejo. El primer sistema, un scaffold de doble capa de alginato-PLGA (ALG-PLGA), conteniendo BMP-2 (2.5 y 5 µg) o TGF-β1 (50 ng) (FC) encapsulados en microesferas de PLGA, controló de manera eficaz la liberación de los FC, y mostró una alta tasa de reparación a las 12 semanas postimplantación, en todos los grupos tratados con FC. El segundo sistema, también de doble capa, incorporó un nuevo poliuretano segmentado (SPU) en sustitución del alginato, y mostró igualmente excelentes resultados en el control de la liberación de los FC, y en la reparación del defecto a las 12 semanas postimplantación, en todos los grupos tratados con FC. En función de varios aspectos, entre ellos la velocidad de degradación de los sistemas, se seleccionó el sistema de ALG-PLGA como el más idóneo, y la BMP-2 a dosis de 5µg como la más adecuada, para evaluar, de forma comparativa, la capacidad condrogénica del tratamiento con células madre mesenquimales derivadas de la médula ósea (MSC) o condrocitos autólogos (rbC), sola


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Product Details
  • ISBN-13: 9783668681040
  • Publisher: Bod Third Party Titles
  • Publisher Imprint: Grin Verlag
  • Height: 210 mm
  • No of Pages: 228
  • Spine Width: 13 mm
  • Width: 148 mm
  • ISBN-10: 366868104X
  • Publisher Date: 19 Apr 2018
  • Binding: Paperback
  • Language: Spanish
  • Returnable: N
  • Weight: 304 gr


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