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Biofilmadsorption Auf Massgeschneiderten Oberflachen: Dynamik Und Morphologische Charakterisierung

Biofilmadsorption Auf Massgeschneiderten Oberflachen: Dynamik Und Morphologische Charakterisierung

          
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About the Book

Die Proteinadsorption an fest-flussig Grenzflachen spielt in einer Vielzahl von Bereichen eine wichtige Rolle. Kommt Speichel in Kontakt mit einer Oberflache, z.B. mit frisch geputzten Zahnen, so bildet sich innerhalb kurzer Zeit eine Schicht definierter Dicke und Zusammensetzung, der sog. initiale orale Biofilm. Neben seiner Schlusselrolle bei der Kolonisation durch Bakterien ubt der proteinreiche Film auch zahlreiche protektive Funktionen aus. Die Gestalt des bakteriellen Biofilms hangt jedoch entscheidend vom Material ab, auf dem die initiale Proteinadsorption stattfindet: Wahrend sich auf Teflon und einigen Nanokompositmaterialien nur eine sehr dunne bakterielle Schicht ausbildet, adsorbiert auf naturlichen Zahnoberflachen deutlich mehr. Die Ursachen dieses Phanomens sind weitestgehend unverstanden, ebenso wie die Tatsache, dass einzelne Enzyme nach der Adsorption aus der Speichelflussigkeit ihre biologische Aktivitat behalten, isolierte adsorbierte Proteine jedoch meist inaktiv sind. Es gibt kein umfassendes fundamentales Modell, um die komplexen Mechnismen und dynamischen Prozesse, die an der Biofilmadsorption beteiligt sind, zu verstehen. Mit einer solchen kompletten Theorie konnte das Verhalten komplexer proteinhaltiger Flussigkeiten vorhergesagt und damit auch die Adsorption gezielt beeinflusst werden. Aufgabe und Ziel dieser Arbeit ist die Charakterisierung der Biofilmadsorption auf massgeschneiderten Oberflachen, mit dem Fokus auf dem Einfluss der Grenzflacheneigenschaften auf den Adsorptionsvorgang. Diese spielen neben den Merkmalen der Proteine selbst und des umgebenden Mediums eine entscheidende Rolle bei der Adsorption.


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Product Details
  • ISBN-13: 9783832521639
  • Publisher: Logos Verlag Berlin
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Sub Title: Dynamik Und Morphologische Charakterisierung
  • Width: 145 mm
  • ISBN-10: 3832521631
  • Publisher Date: 24 Feb 2009
  • Height: 210 mm
  • No of Pages: 290
  • Spine Width: 0 mm
  • Weight: 700 gr

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