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Bases moléculaires de la résistance des vih-1 sous-types non-b aux arv

Bases moléculaires de la résistance des vih-1 sous-types non-b aux arv

          
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About the Book

Un des défis de la lutte contre le VIH est de caractériser la résistance développée par le VIH aux ARV. Or, les connaissances portent essentiellement sur le sous-type B du VIH-1 circulant majoritairement dans les pays industrialisés. Il est important d'étudier les bases moléculaires de la résistance du VIH-1 de sous-type non-B avec l'accès de plus en plus important aux ARV au Sud. Nous avons montré que lors d'un échec précoce nous avons des profils de mutations au 3TC (M184V) et aux INNTI (K103N et Y181C). Nous avons étudié la prévalence de la résistance primaire et la caractérisation des sous-types de VIH-1 circulant au Mali et nous avons obtenu une prévalence de 11,5%. Deux sous-types (B et CRF02_AG) etudies dans nos travaux ont une barrière génétique (BG) similaire, mais on note une BG plus élevée pour le CRF02_AG a certaines positions de l'integrase. Nous avons obtenu 10% de virus portant des mutations de résistance à l'ETR chez patients infectés par des sous-types non-B et naïfs d'ARV. Ces données sont importantes à prendre en compte pour l'établissement des 2èmes et 3èmes lignes de traitement ARV dans les pays du Sud.


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Product Details
  • ISBN-13: 9786131582714
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Height: 229 mm
  • No of Pages: 176
  • Series Title: Omn.Univ.Europ.
  • Weight: 267 gr
  • ISBN-10: 6131582718
  • Publisher Date: 28 Feb 2018
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 10 mm
  • Width: 152 mm


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