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Ação antitumoral de Oliveira e flavonoides

Ação antitumoral de Oliveira e flavonoides

          
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About the Book

Os flavonoides são compostos orgânicos, extraídos de plantas, conhecidos pelas suas propriedades farmacológicas, dentre elas, a atividade anticarcinogênica. A família da Olea europaea L. conhecida como oliveiras, possui aplicação medicinal na região onde é cultivada. Neste trabalho foi avaliada a atividade citotóxica de três flavonoides (morina, naringina, rutina) e do extrato da folha de oliveira contra às linhagens leucêmicas: U937, THP-1 e linhagens de tumores sólidos: B16F10, SK-MEL-5, H460 via ensaio colorimétrico MTT e pelo índice da lactase desidrogenase (LDH) liberada pela célula opôs 48 horas de incubação. Estes ensaios mostraram que o composto morina e o extrato de oliveira reduziram a viabilidade celular de maneira concentração dependente nas linhagens tumorais. A análise por microscopia de fluorescência mostrou que o flavonoide morina e o extrato de oliveira foram os únicos efetivos em induzir morte por apoptose de maneira tempo e concentração dependentes nas linhagens U937, THP-1, SK-MEL-5, B16F10.H460.


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Product Details
  • ISBN-13: 9786139707829
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Novas Edicoes Academicas
  • Height: 229 mm
  • No of Pages: 132
  • Spine Width: 8 mm
  • Width: 152 mm
  • ISBN-10: 613970782X
  • Publisher Date: 04 Dec 2018
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 204 gr


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