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Automatisierung der morphometrischen Analyse des Neokortex von Tau-transgenen Mäusen

Automatisierung der morphometrischen Analyse des Neokortex von Tau-transgenen Mäusen

          
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About the Book

Bachelorarbeit aus dem Jahr 2008 im Fachbereich Medizin - Sonstiges, Note: 1,3, Universität Osnabrück, Sprache: Deutsch, Abstract: Die Alzheimer-Krankheit ist eine degenerative Hirnerkrankung mit progredienter Hirnatrophie (bis zu zehn Prozent) unter Bildung bestimmter pathologischer Veränderungen im Gehirn. Tau bildet im Gehirn von Alzheimer-Patienten fibrilläre Aggregate ("neurofibrillary tangles", NFTs) in Neuronen und krankheitstypische Tauformen ("paired helical filaments", PHFs) im Gehirn. Dies führt zu einer Fehlfunktion der Mikrotubuli, was wahrscheinlich zum Zelltod der Neurone in Tauopathien wie bei Alzheimer führt. Um mehr über die Hintergründe zu erfahren, die den Gewebsverlust verursachen, wurde der Neokortex (NC) von tau-transgenen Mäusen, so wie der von nicht-transgenen Kontrolltieren morphometrisch analysiert. Dabei wurden Mäuse verwendet, die transgen für Wildtyp-Tau oder für eine pseudohyperphosphorylierte Variante von Tau (PHP-Tau) waren. Hierbei wurden sowohl die Dichte als auch die Größe der Neurone im NC bestimmt. Für die Analyse wurden Hirnschnitte in 50 μm Dicke angefertigt, in denen die Nervenzellkörper durch NeuN Immunfärbung deutlich sichtbar sind. Nach Erstellen von Bildern des gewünschten Analysebereiches mit einem konfokalen Laser-Scanning-Mikroskop wurde die Bildserie mit der Software ImageJ bearbeitet. Da die Bestimmung der Neuronenanzahl sowie der Neuronendichte von jedem einzelnen Bild erfolgen muss, war diese Art der Analyse sehr zeitaufwendig. Ziel der Arbeit war es, die morphometrische Analyse zu automatisieren und eine neue Analysemethode zu etablieren. Dies wurde erreicht, in dem zwei Plugins geschrieben wurden, die es ermöglichen einen Arbeitsschritt auch an einer Bildserie anwenden zu können. Die Automatisierung gewährleistet so eine schnelle und fehlerfreie Analyse, da Bearbeitungsfehler auf ein Minimum reduziert werden. Dadurch wird eine effiziente und standardisierte Bearbeitung des gesamten Datensatzes möglich. Da es Unte


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Product Details
  • ISBN-13: 9783640112821
  • Publisher: Grin Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 7 mm
  • Width: 148 mm
  • ISBN-10: 3640112822
  • Publisher Date: 29 Jul 2008
  • Height: 210 mm
  • No of Pages: 108
  • Series Title: German
  • Weight: 154 gr


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