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Aspects Of Crystallography In Molecular Biology

Aspects Of Crystallography In Molecular Biology

          
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About the Book

X-ray Crystallography is used as a major tool in Structural Molecular Biology to understand biological processes at the molecular level. This edited volume consisting of three parts presents some of the aspects of Crystallography as well as its applications to Biology. Part I provides an overview of Crystallography. Part II deals with some of the special techniques in Macromolecular Crystallography, such as crystallisation of proteins and nucleic acids, synchrotron radiation and its properties, multiple isomorphous replacement method, direct methods etc. This part also contains an account of the quaternary structure of proteins, problem of thermal vibration and disorder etc. Part III is mainly concerned with structure/function studies of bacillus signal peptides, phospholipase A2, sulphate reducing bacteria proteins, FAB - R68K Lysozyme complex, phosphocarpin B1 and a few other biomolecules. Molecular modelling studies of human cathepsin D and rice rubisco are also dealt with in this part. The application of NMR imaging in biology is also briefly covered. This part culminates with an account of nucleotide conformations, and the general principles of protein-nucleic acid interactions. The articles in this volume would be useful to those engaged in teaching and research in Crystallography, Structural Biology and related fields.About the AuthorS. Parthasarathy, is a young teacher of postgraduate students in one of the well-established engineering colleges in Tamil Nadu and the whole of India, the Thiagarajar College of Engineering (Autonomous), Madurai. Starting with B.Sc. degree in Mathematics, he went on to acquire M.C.A. from the Madurai Kamaraj University, Madurai, M.Phil., degree in Computer Science from Bharathidasan University, Tiruchirappalli, P.G.D.B.A. (Business Administration) from Pondicherry University and P.G.D.P.M. (Planning and Project Management) from University of Hyderabad. A habitual rank holder, he is now working for his Ph.D., in Computer Science from Anna University, Chennai.Table of ContentsPart I: An Overview of Biocrystallography Biocrystallography: An Overview Part II: Special Techniques/Topics in Biocrystallography Crystallisation of Proteins Crystallisation of Oligonucleotides Automatic Processing of Rotation Diffraction Data from Crystals of Initially Unknown Symmetry and Cell Constants Multiple Isomorphous Replacement Method The Role of Direct Methods in Macromolecular Crystallography The Application of Synchrotron Radiation for Macromolecular Crystallography A Theoretical Study on the Measurability of Bijvoet Differences in Macromolecular Crystals Theory and Application of a New Algorithm for Phasing X-Ray Reflections using Maximum Entropy Rule-Based Comparative Modelling of Human Cathepsin D: A Retrospective Comparison with the Crystal Structure Molecular Modelling of Rice Rubisco An Integrated X-Ray Measurement and Computation System in Protein Crystallography The Problem of Thermal Motion and Disorder in Crystallography C-H...O Hydrogen Bonding and its Importance in Molecular Recognition and Crystal Engineering Quaternary Structure of Proteins Macromolecular Structural Characterisation, Data Analysis and Representation. Part III: Results Related to Biomolecular Structure Structure-Function Studies on Bacillus Signal Peptides The Structure and Function of Phospholipase A2 Structure-Function Studies of Proteins in Sulfate-Reducing Bacteria An FAB in Complex with R68K Lysozyme: Crystal Structure and Analysis Crystal Structure of Psophocarpin B1: A Chymotrypsin Inhibitor from Winged Bean Seeds A Three Dimensional Model of a Monoclonal Antibody by Homology X-Ray Experiments and Structure Analyses of Biological Macromolecules with a Large Unit Cell The Role of in vivo Nuclear Magnetic Resonance Spectroscopy in Molecular Biology Oligonucleotides with Complementary and Non-Complementary Base Pairing and their Ligand Complexes-Major and Minor Nucleotide Conformations Perturbed and Unperturbed DNA: The Effect of A.T Base Pairs on the Structure of Z DNA Protein-Nucleic Acid Interactions: General Principles Crystallographic Studies of Nucleic Acid Deformability.


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Product Details
  • ISBN-13: 9788122410839
  • Publisher: New Age International
  • Binding: Hardcover
  • Language: English
  • ISBN-10: 8122410839
  • Publisher Date: 2010
  • Edition: 1stEdition

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