Major disruption worldover is due to artificial intelligence (AI), blockchain, 3D organ printing and others. Almost all the industries are being affected by AI. Health sector, particularly pharmaceutical sciences is also not an exception. The book has been designed to cover all the basic topics and examples related to artificial intelligence (AI), machine learning (ML) and deep learning (DL) and their application in drug discovery in detail. The book has been designed to cover basics and role of AI in drug discovery, including clinical trials and other departments of health and pharmaceutical sciences. More and more pharma companies are using AI and its subsets for increasing productivity in terms of drug discovery (de novo drug design, repurposing), manufacturing, clinical trials (subject selection, data recording and analyzing, minimizing dropping out of subjects etc.), synthesis and others. In this book, different types of tasks, machine learning can handle, have been described in a very easy-to-understand fashion, besides types of machine learning (like supervised, unsupervised and reinforcement learning), machine learning algorithms etc. Basics like definitions of machine learning model, features, vectors, weights, biases, training, testing, data processing etc. all are covered in detail. Various types of artificial neural networks like convolutional neural network, recurrent neural network, autoencoders and its types like variational autoencoder, adversarial autoencoder and much talked about that is generative adversarial network have also been covered in a significant manner. All the content has been compiled after referring and mining hundreds of latest and original first-hand updates from inventors, experts, organizations (who/which are engaged in drug discovery research directly or indirectly through AI) like Insilico, Google, Microsoft, INVIDIA, Novartis, Intel, IBM, Exscientia, Berg, Atomwise, XtalPi, Recursion, H2OAi, Recursion, BenevolentAI, Minds.ai, Deep Genomics, AiCure, Trials.ai, GNS Healthcare, MIT, Okwin, Flatiron, Syapse etc. It was unavoidable to explore content from websites and newspapers as authors were interested to cover latest content. All topics are explained in very simple language with clear aim and outcome using flow charts, tables and infographics. Professionals from medical, pharmacy, pharma industries, nursing and dental and medical imaging arena will find this book very useful if they want to explore the basics and applications of AI. Students of all levels will find book very beneficial as few topics have been just touched, few have been shallow in complexity and rest are covered in detail. Full precaution has been exercised to address the needs of learners from non-maths background so that they can easily and effortlessly understand the subject matter of this book. Recent examples from various corporates, universities and daily life have found place in this unique book in a very explicit manner.At relevant section, coding that is programming basics have been shared for beginners who wants to write python codes on their own. This has been explained in step-by-step manner in a reproducible manner, starting from installing conda environment on their local machine to importing package like numpy, pandas etc. in their jupyter notebook. Famous examples of Iris database, Pima diabetes dataset, Wisconsin breast cancer database and others have been shared as screenshots so that learners can type exactly same codes in their jupyter notebook and learn how to import excel CSV file that is respective dataset, defining x and y variables, splitting and defining % of train and test dataset, running model and finally analyzing the prediction. This has been done to bring non-maths learners as close as possible to these topics which are running the world. At the end, questions have been added for the readers, mainly students. Authors are always open to suggestions, comments from our valuable readers.