Preface
Chapter 1: Cell line development
Hansjoerg Hauser
Chapter 2: Transient recombinant protein expression in mammalian cells
Volker Jäger, Konrad Büssow, Thomas Schirrmann
Chapter 3: Hybridoma technology for the in vitro production of therapeutic antibodies
Susan McDonnell
Chapter 4: Bioreactors for mammalian cells
R. Pörtner
Chapter 5: Mass Transfer and Mixing Across the Scales in Animal Cell Culture
Alvin W Nienow
Chapter 6: Hydrodynamic Damage to Animal Cells
Jeffrey J Chalmers and Ningning Ma
Chapter 7: Monitoring of cell culture
Sebastian Schwamb, Robert Puskeiler, Philipp Wiedemann
Chapter 8: Serum and protein free media
Michael Butler
Chapter 9: Glycosylation in Cell Culture
Maureen Spearman and Michael Butler
Chapter 10: Modelling of mammalian cell cultures
Nishikant P. Shirsat, Niall J. English, Brian Glennon and Mohamed Al-Rubeai
Chapter 11: Mammalian Cell Line Selection Strategies for High-Producers
Darrin Kuystermans and Mohamed Al-Rubeai
Chapter 12: Building a Cell Culture Process with Stable Foundations: Searching for Certainty in an Uncertain World
Peter M O'Callaghan and Andrew J Racher
Chapter 13: Perfusion Processes
Veronique Chotteau
Chapter 14: Single-use bioreactors for animal and human cells
Stephan C. Kaiser, Matthias Kraume, Dieter Eibl, and Regine Eibl
Chapter 15: An Overview of Cell Culture Engineering for the Insect Cell-Baculovirus Expression Vector System (BEVS)
Laura A. Palomares, Mauricio Realpe and Octavio T. Ramirez
Chapter 16: Metabolic flux analysis: a powerful tool in animal cell culture
João V. Sá, Tiago M. Duarte, Manuel J. T. Carrondo, Paula M. Alves, Ana P. Teixeira
Chapter 17: Cell immobilization for the production of viral vaccines
Ana Carina Silva, António Roldão, Ana Teixeira, Paulo Fernandes, Marcos F.Q. Sousa, Paula M. Alves
Chapter 18: Cell Engineering for Therapeutic Protein Production
Eric Baek, Che Lin Kim, Jin Hyoung Park, and Gyun Min Lee
Chapter 19: Proteomics in Cell Culture: From genomics to combined 'omics for cell line engineering and bioprocess development
Kelley Heffner, Christian Kaas, Amit Kumar, Deniz Baycin-Hizal, Michael Betenbaugh
Chapter 20: Metabolomics in animal cell culture
Miroslava Čuperlovic-Culf
Chapter 21: Process Analytical Technology and Quality-by-Design for Animal Cell Culture
Stephen Craven and Jessica Whelan
Chapter 22: Biosafety recommendations on the handling of animal cell cultures
Philippe Herman and Katia Pauwels
Chapter 23: Biopharmaceutical products from animal cell culture
Darrin Kuystermans and Mohamed Al-Rubeai
Index
