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Aktuelle Aspekte Zur Bakteriologischen Resistenzbestimmung Und Resistenzsituation

Aktuelle Aspekte Zur Bakteriologischen Resistenzbestimmung Und Resistenzsituation

          
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About the Book

Die groBe Bedeutung der Bakterienplasmide, insbesondere der R- Faktoren, ergibt sich aus ihrem Gehalt an Genen, welche die Anpas- sungsfahigkeit ihrer Wirtskeime an besondere Umgebungssituatio- nen und daruber hinaus die evolutionare Flexibilitat sicherstellen. Sie haben auBerdem die Aufgabe, den prokaryontischen Wirtskeimen die Fahigkeit zu vermitteln, ihre durch Mutationen unbrauchtJar geworde- ne Erbsubstanz durch funktionsfahige zu ersetzen. Den Eukaryonten stehen hierzu die sexuellen Rekombinationsmbglichkeiten zur Verfu- gung. Die R-Faktoren haben deshalb uber die Vermittlung von Resi- stenzeigenschaften hinaus EinfluB auf die Entwicklung nosokomialer Infektionen. Da ihre Verbreitung bereits ein groBes AusmaB ange- nom men hat, sollte ihre weitere Selektion bei Krankheitserregern ein- geschrankt werden. Neben der Vermeidung unnbtiger Antibiotikaga- ben in der Klinik und in auBermedizinischen Bereichen sollten solche Antibiotika bevorzugt werden, die R-Plasmide nicht selektieren. Hier- zu gehbrt Fosfomycin, welches trotz intensiver Verwendung bislang noch keine plasmidische Resistenzentwicklung zu erkennen gab. Auch eigene Untersuchungen sprechen dafUr, daB noch keine plas- midische Fosfomycin-Resistenz aufgetreten ist. Allerdings ist die An- wendungszeit noch nicht lange genug, um zukunftige Entwicklungen in diese Richtung vbllig auszuschlieBen. Literatur 1. Hayes, w.: The genetics of bacteria and their viruses. Blackwell Scientific publications, Oxford and Edinburgh (1964). 2. Tschaepe, H. und E. Tietze: Genetische und molekulare Grundlagen der Plasmid-Species-Hypothese. BioI. Zbl. 100(1981) 353-84. 3. Jacob, F and J. Monod: Genetic regulatory mechanisms in the synthesis of proteins, Journal of Molecular Biology, 3 (1961) 318-356. 4. Lebek, G., W. Haefliger und R.


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Product Details
  • ISBN-13: 9783663019374
  • Publisher: Vieweg+teubner Verlag
  • Binding: Paperback
  • Height: 210 mm
  • No of Pages: 95
  • Series Title: German
  • Weight: 131 gr
  • ISBN-10: 3663019373
  • Publisher Date: 10 Nov 2012
  • Edition: 1982 ed.
  • Language: German
  • Returnable: Y
  • Spine Width: 5 mm
  • Width: 148 mm


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