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Aging of the Genome: The Dual Role of DNA in Life and Death

Aging of the Genome: The Dual Role of DNA in Life and Death

          
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About the Book

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.


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Product Details
  • ISBN-13: 9780198569237
  • Publisher: OUP Oxford
  • Publisher Imprint: Oup Oxford
  • Edition: 1
  • Language: English
  • Returnable: N
  • Spine Width: 20 mm
  • Weight: 861 gr
  • ISBN-10: 0198569238
  • Publisher Date: 01 Apr 2007
  • Binding: Paperback
  • Height: 244 mm
  • No of Pages: 384
  • Series Title: English
  • Sub Title: The Dual Role of DNA in Life and Death
  • Width: 188 mm


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