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Administração pulsátil de medicamentos com indometacina

Administração pulsátil de medicamentos com indometacina

          
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About the Book

Foram desenvolvidas seis formulações de cápsula de pulso modificada de indometacina utilizando vários graus e proporções, usando hidroxipropilmetilcelulose K-100M, CCS como polímeros de controlo da taxa. O esterato de magnésio e o talco são os outros componentes utilizados. As misturas foram avaliadas em relação a vários parâmetros, tais como a densidade aparente, a densidade de batida, o ângulo de repouso, o rácio de Hausner e o índice de Carr. As cápsulas foram avaliadas quanto ao seu aspeto físico, teor de fármaco, % de variação de peso e libertação de fármaco in vitro. Todas as propriedades físico-químicas estão dentro dos limites aceitáveis. Com base nos resultados, a formulação F6 contendo HPMC-K100M na concentração do dobro da concentração do fármaco foi identificada como uma formulação ideal e melhor entre todas as formulações. A libertação in-vitro de uma formulação optimizada de indometacina (f6) foi de 96,05% em 4 horas. Com base nos valores do coeficiente de regressão (R2 ) de vários gráficos, verificou-se que a formulação optimizada seguia o modelo de libertação de primeira ordem e que o mecanismo de libertação do fármaco era do tipo de difusão não fickiana com base no valor "n" do modelo de Korsemeyer-Peppas.


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Product Details
  • ISBN-13: 9786207237005
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 76
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6207237005
  • Publisher Date: 06 Mar 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 127 gr


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