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Administration pulsatile de médicaments à base d'indométhacine

Administration pulsatile de médicaments à base d'indométhacine

          
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About the Book

Six formulations de pulsincap modifié d'Indométhacine ont été développées en utilisant différents grades et ratios en utilisant l'Hydroxy propyl méthyl cellulose K-100M, CCS comme polymères de contrôle du taux. Le stéarate de magnésium et le talc sont les autres composants utilisés. Les mélanges ont été évalués en fonction de divers paramètres tels que la densité apparente, la densité tassée, l'angle de repos, le rapport de Hausners et l'indice de Carr. Les gélules ont été évaluées en fonction de leur aspect physique, de leur teneur en médicament, de la variation de poids en % et de la libération du médicament Invitro. Toutes les propriétés physico-chimiques se situent dans les limites acceptables. Sur la base des résultats, la formulation F6 contenant du HPMC-K100M à une concentration double de celle du médicament a été identifiée comme une formulation idéale et meilleure parmi toutes les formulations. La libération in vitro d'une formulation optimisée d'indométacine (F6) s'est avérée être de 96,05 % en 4 heures. D'après les valeurs du coefficient de régression (R2 ) des différents tracés, la formulation optimisée suit le modèle de libération du premier ordre et le mécanisme de libération du médicament est un type de diffusion nonickien basé sur la valeur 'n' du modèle de Korsemeyer-Peppas.


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Product Details
  • ISBN-13: 9786207236985
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 76
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 620723698X
  • Publisher Date: 06 Mar 2024
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 127 gr


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