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Activité du nouvel inhibiteur de la kinase BCR IQS019 dans le lymphome lymphoïde à cellules B

Activité du nouvel inhibiteur de la kinase BCR IQS019 dans le lymphome lymphoïde à cellules B

          
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About the Book

La leucémie lymphocytaire chronique, le lymphome à cellules du manteau, le lymphome folliculaire et le lymphome diffus à grandes cellules B représentent divers sous-types de néoplasmes lymphoïdes à cellules B, avec des différences essentielles dans l'origine cellulaire, la progression de la maladie et la réponse au traitement. La signalisation du récepteur des cellules B (BCR) est récemment apparue comme une voie oncogène centrale dans ces modèles, favorisant la croissance et la survie des tumeurs. Nous décrivons ici un nouvel inhibiteur de kinases liées au BCR, IQS019, qui interagit avec la phosphorylation activatrice de trois kinases apicales du BCR (Syk, Lyn et Btk) et la prévient efficacement dans ces modèles. L'inhibition de la signalisation BCR par IQS019 entraîne une réduction de la prolifération cellulaire, un blocage du chimiotactisme cellulaire et une augmentation de l'apoptose dépendante de la caspase. De plus, dans deux modèles différents de xénogreffes de souris, le traitement par IQS019 entraîne une diminution remarquable de la phosphorylation de la kinase BCR et de l'indice mitotique, une réduction de la charge tumorale et de l'infiltration des cellules tumorales dans la rate. Dans l'ensemble, ces résultats justifient la poursuite des recherches et le développement clinique de ce nouvel inhibiteur de la kinase BCR dans les tumeurs malignes lymphoïdes B matures.


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Product Details
  • ISBN-13: 9786207368440
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 68
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 6207368444
  • Publisher Date: 10 Apr 2024
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 113 gr


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