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Acides terpéniques modifiés de Boswellia serrata: Activité biologique

Acides terpéniques modifiés de Boswellia serrata: Activité biologique

          
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About the Book

Isolement et identification de triterpinoïdes pentacycliques naturels (acides boswelliques), de triterpnoïdes tétracycliques (acides tirucalliques) provenant de Boswellia serrata. Synthèse de nouvelles molécules hybrides utilisant des acides boswelliques avec des AINS et étude de leur activité anti-inflammatoire et anti-arthritique sur des modèles in vivo. Amélioration d'une molécule biologiquement puissante à partir d'un mélange naturel d'acides boswelliques en les convertissant en un seul par oxydation allylique à l'aide de divers agents oxydants et optimisation du meilleur d'entre eux. Des nanoparticules d'acide boswellique ont été préparées et analysées à l'aide de la technique SEM. Les acides boswelliques naturels, qui sont des agents anti-inflammatoires, sont de nature lipophylique et deviennent donc un facteur limitant en termes de biodisponibilité. C'est pourquoi, pour la première fois, des glycosides hydrosolubles d'acides 11-céto-β-boswelliques ont été préparés avec succès. Synthèse de nouveaux composés modifiés par l'anneau A via un réarrangement de Beckmann de deuxième ordre à partir de l'acide 3-oxo-tircallic; évaluation de leur activité anticancéreuse contre des lignées de cellules cancéreuses humaines et découverte que les composés modifiés par l'anneau A ont montré une activité anticancéreuse améliorée, en particulier sur la lignée de cellules cancéreuses de la prostate.


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Product Details
  • ISBN-13: 9786207890644
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 96
  • Spine Width: 6 mm
  • Weight: 154 gr
  • ISBN-10: 6207890647
  • Publisher Date: 31 Jul 2024
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Sub Title: Activité biologique
  • Width: 152 mm


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