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15-Deoxy-Delta(12,14)-Prostaglandin J2 als Modulator der Makrophagenfunktion

15-Deoxy-Delta(12,14)-Prostaglandin J2 als Modulator der Makrophagenfunktion

          
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About the Book

Bachelorarbeit aus dem Jahr 2015 im Fachbereich Gesundheit - Ernährungswissenschaft, Note: 1,5, Friedrich-Schiller-Universität Jena, Veranstaltung: Biochemie der Ernährung, Sprache: Deutsch, Abstract: Die Atherosklerose stellt eine der primären Ursachen für kardiovaskuläre Erkrankungen dar. Im Prozess der Entstehung und der Progression dieses Krankheitsbildes nehmen Makrophagen eine entscheidende Rolle ein. Aus diesem Grund haben es sich Arbeitsgruppen aus aller Welt zur Aufgabe gemacht, die molekularen Mechanismen in Makrophagen, welche zur Etablierung des Krankheitsbildes der Atherosklerose führen, aufzuklären und in diesen potentielle Angriffspunkte für Therapeutika gegen Atherosklerose ausfindig zu machen. Im Zuge solcher Untersuchungen wurde 15d-PGJ2 als vielversprechender endogener PPARγ-Ligand mit potentieller antiinflammatorischer Wirkung identifiziert und in den Mittelpunkt jahrelanger Forschung gerückt. Ziel dieser Arbeit ist es, anhand einschlägiger Literatur die Effekte, welche 15d-PGJ2 auf die Genexpression in Makrophagen ausübt, und deren Folgen für das Fortschreiten der Atherosklerose zu analysieren. In zahlreichen In-vivo- und In-vitro-Untersuchungen konnte gezeigt werden, dass 15d-PGJ2 antiatherogene Effekte erzielt, indem es in Signalwege und Genregulationsmechanismen eingreift und auf diese Weise die Genexpression in Makrophagen moduliert. Durch die Aktivierung von PPARγ induziert 15d-PGJ2 vorwiegend die Expression von Genen, deren Produkte maßgeblich an der Lipidhomöostase in Makrophagen und Schaumzellen beteiligt sind. So fördert 15d-PGJ2-aktivierter PPARγ beispielsweise die Expression des Scavenger-Rezeptors CD36 in Makrophagen, was zunächst in einer erhöhten Aufnahme von oxLDL resultiert. Durch anschließende Förderung des reversen Cholesterintransportes schützt PPARγ die Arterienwand vor der Exposition mit großen Mengen an oxLDL und vor ausufernder Schaumzellbildung. Darüber hinaus inhibiert 15d-PGJ2 durch das Einschreiten in unterschiedl


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Product Details
  • ISBN-13: 9783668374171
  • Publisher: Grin Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 4 mm
  • Width: 148 mm
  • ISBN-10: 3668374171
  • Publisher Date: 18 Jan 2017
  • Height: 210 mm
  • No of Pages: 62
  • Series Title: German
  • Weight: 95 gr


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15-Deoxy-Delta(12,14)-Prostaglandin J2 als Modulator der Makrophagenfunktion
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