Joao Batista Rocha

Joao Batista RochaDr. Rocha serves as full professor of toxicological biochemistry at the Departament of Biochemistry and Molecular Biology in the Center of Natural and Exact Sciences, FederaL University of Rio Grande do Sul, Brazil. He researches areas include the us of alternative invertebrate models in neurotoxicology and the interaction of mercury forms with the selenol group of selenoproteins and low-molecular mass selenium-containing molecules One important subtopic focused in the interaction of methylmercury and Hg2+ with thiol- and selenol-containing molecules both in silico and in vitro. The main aims of in vitro studies are to determine how mercury disrupt the thiol- and selenol-containing proteins in the nervous system of invertebrates. The in silico studies aims are to develop chemical and biochemical models to predict how electrophilic mercury forms can disrupt the function of thiol- and selenol-containing proteins. Specially, on how the interaction of Hg forms can impair the cell redox environment by inactivating or sequestering the trace element selenium. He has authored (co-authored) >500 peer reviewed manuscripts and 20 book chapter and is associated editor of Neurotoxicology and the Journal of Animal Physiology and Animal Nutrition. Read More Read Less

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Toxicology of Essential and Xenobiotic Metals7 % NR
Publisher: CRC Press
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15 Oct 2024
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Alternative Methods in Neurotoxicology8 % NR
Publisher: Elsevier Science
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01 Jun 2023
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