Jim R FadelJim Fadel is a Professor of Pharmacology, Physiology and Neuroscience at the University of South Carolina School of Medicine. His initial interest in the orexin/hypocretin system began as a postdoctoral fellow with Dr. Ariel Deutch, where he describe the anatomical basis for orexin-dopamine interactions and identified orexin neurons as targets of antipsychotic drugs associated with weight gain (Fadel & Deutch, 2002; Fadel et al., 2002). Since then, he has focused extensively on anatomical and neurochemical mechanisms underlying orexin effects on cognition. With his long-time collaborator, Dr. Burk, he has shown that orexins play important roles in regulating attentional functions which stem, in part, from their effects on the basal forebrain cholinergic system (e.g. Fadel & Burk, 2010; Frederick-Duus et al., 2007). Dr. Fadel's lab has also demonstrated loss of orexin neurons in their aged rat model (Kessler et al., 2010), a phenomenon proposed to link age-related alterations in homeostasis with cognition (Stanley & Fadel, 2012; Fadel et al., 2013). Read More Read Less