Charlotte E TeunissenCharlotte Teunissen's research mission is to cure dementia disorders through development of body fluid biomarkers. The studies of her research group cover the entire spectrum of biomarker development. The studies start with biomarker identification, ypothesis based as well as by mass spectrometry based proteomics method, including mass spectrometry and aptamer-based proteomics technologies. The group puts strong effort in analytical validation of the most promising biomarkers by available immunoassays, which we also develop ourselves. In the next step, extensive internal and external clinical validation are performed and the last type of studies are aimed at implementation of novel biomarkers in clinical practice. The lab possesses state of the art technologies, such as SOMAscan, Quanterix ultrasensitive SimOA technology, Mesoscale technology and in vitro technologies for clinical routine lab analysis. These studies are all based on the availability of a well-characterised biobank, headed by me, of >4000 paired CSF and serum samples of dementia patients (a.o. Alzheimer, Frontotemporal, Lewy Bodies) and controls with subjective complaints, that visit the Alzheimer Center Amsterdam outpatient clinic. To ensure the quality of biosamples, Teunissen performs scientific studies to detect e.g. sentinel biomarkers, and take the lead in guideline development for CSF biomarker study methodology. Teunissen has always collaborated strongly in the field, as this is a prerequisite for performing high quality biomarker studies, visible in her lead in the BioMS network, the Society for Neurochemistry and routine CSF analysis, and the Alzheimer Association-global biomarker standardization consortium. Read More Read Less