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Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

          
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About the Book

Claus W. Heizmann and Katharina Braun ore than 10,000 articles were published in 1994 on calcium, M 2 emphasizing the widespread interest and progress in Ca +- 2 related research. This book focuses mainly on Ca + -binding pro- 2 teins in the central nervous system, where Ca + ions have been found to activate fundamental processes such as release of neu- rotransmitters, axonal flow, long term potentiation, cell motility, differentiation, secretion, and apoptosis. It has also been found that a number of neurodegenerative disorders have been attributed 2 1 to aberrations of intracellular Ca + homeostasis. 2 2 Intracellular Ca + levels and Ca + signaling within cells must 2 3 2 be tightly controlled. - Ca + overload as a result of seizures or ischemia is supposed to activate biochemical processes, leading to enzymatic breakdown of proteins and lipids, malfunctioning of 2 mitochondria, energy failure and ultimately cell death. There is 3 experimental evidence that electrically induced irreversible depo- larization of hippocampal neurons, which may be an early indica- 2 tion of neuronal damage, could be prevented by injecting Ca + chelators and thereby increasing intracellular buffering capacity. Thus, it is reasonable to assume that neurons containing certain 2 intracellular Ca +-binding proteins, and therefore having a greater 2 capacity to buffer Ca +, could be more resistant to degeneration.


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Product Details
  • ISBN-13: 9783662216910
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Binding: Paperback
  • Height: 254 mm
  • No of Pages: 139
  • Series Title: Neuroscience Intelligence Unit
  • Weight: 290 gr
  • ISBN-10: 3662216914
  • Publisher Date: 20 Nov 2013
  • Edition: Softcover reprint of the original 1st ed. 1995
  • Language: English
  • Returnable: Y
  • Spine Width: 9 mm
  • Width: 178 mm


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